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New insights on the role of lipid metabolism in the metabolic reprogramming of macrophages
(Frontiers Media, 2020)
Macrophage activation is intimately linked to metabolic reprogramming. Inflammatory (M1) macrophages are able to sustain inflammatory responses and to kill pathogens, mostly by relying on aerobic glycolysis and fatty acid ...
Muscle lipid metabolism: role of lipid droplets and perilipins
(Hindawi, 2017)
Skeletal muscle is one of the main regulators of carbohydrate and lipid metabolism in our organism, and therefore, it is highly susceptible to changes in glucose and fatty acid (FA) availability. Skeletal muscle is an ...
Lipid droplets are both highly oxidized and Plin2-covered in hepatocytes of diet-induced obese mice
(Canadian Science Publishing, 2020)
Chronic high-fat diet feeding is associated with obesity and accumulation of fat in the liver, leading to the development of insulin resistance and nonalcoholic fatty liver disease. This condition is characterized by the ...
Cholesterol, glucose and triglycerides role in the prevalence of hyperlipemia in dogs at higher elevations
(2011)
Hyperlipidemia is a metabolic disorder that is characterized by a fat concentration increase in blood serum and it is known to be common in dogs. However, there is no information about how this disorder behaves in different ...
Chaperone mediated autophagy in the crosstalk of neurodegenerative diseases and metabolic disorders
(Frontiers Media, 2019)
Chaperone Mediated Autophagy (CMA) is a lysosomal-dependent protein degradation pathway. At least 30% of cytosolic proteins can be degraded by this process. The two major protein players of CMA are LAMP-2A and HSC70. While ...
Metabolic flexibility and insulin resistance
(AMER PHYSIOLOGICAL SOC, 2008-11)
Metabolic flexibility is the capacity for the organism to adapt fuel oxidation to fuel availability. The inability to modify fuel oxidation in response to changes in nutrient availability has been implicated in the ...
Fatty acid and lipid metabolism in liver of pregnant mice and their offspring is influenced by unbalanced folates/vitamin B12 diets
(Elsevier, 2020)
Micronutrients (folates and vitamin B12) and long chain polyunsaturated fatty acids (LC-PUFAs) are linked through the one carbon cycle. We studied the effects of pre and postnatal high FA/low B12 diets (HFLB12) on hepatic ...
Dynamic flux balance analysis of biomass and lipid production by Antarctic thraustochytrid Oblongichytrium sp. RT2316‐13
(Wiley, 2020)
Production of biomass and lipids in batch cultures of the Antarctic thraustochytridOblongichytriumsp. RT2316-13, is reported. The microorganism proved capable of producing nearly 67% docosahexaenoic acid (DHA) and 15% ...
Lipid Metabolizing Enzyme Activities Modulated by Phospholipid Substrate Lateral Distribution
(2011)
Biological membranes contain many domains enriched in phospholipid lipids and there is not yet clear explanation about how these domains can control the activity of phospholipid metabolizing enzymes. Here we used the surface ...
Lipid composition of purified transverse tubule membranes isolated from amphibian skeletal muscle
(1987)
The level and proportion of lipids and their fatty acid composition were analyzed in highly purified transverse tubule membranes of amphibian skeletal muscle. Tubule membranes show (a) a higher content of lipids, (b) a ...