Artículo de revista
Lipid Metabolizing Enzyme Activities Modulated by Phospholipid Substrate Lateral Distribution
Fecha
2011Registro en:
Bulletin of Mathematical Biology, Volumen 73, Issue 9, 2018, Pages 2045-2067
00928240
15229602
10.1007/s11538-010-9602-8
Autor
Salinas, Dino G.
Reyes, Juan G.
de la Fuente, Milton
Institución
Resumen
Biological membranes contain many domains enriched in phospholipid lipids and there is not yet clear explanation about how these domains can control the activity of phospholipid metabolizing enzymes. Here we used the surface dilution kinetic theory to derive general equations describing how complex substrate distributions affect the activity of enzymes following either the phospholipid binding kinetic model (which assumes that the enzyme molecules directly bind the phospholipid substrate molecules), or the surface-binding kinetic model (which assumes that the enzyme molecules bind to the membrane before binding the phospholipid substrate). Our results strongly suggest that, if the enzyme follows the phospholipid binding kinetic model, any substrate redistribution would increase the enzyme activity over than observed for a homogeneous distribution of substrate. Besides, enzymes following the surface-binding model would be independent of the substrate distribution. Given that the distrib