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JNK mediates TGF-beta 1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes
(ELSEVIER, 2006-10-02)
In this study we analyzed the role of the c-Jun N-terminal kinases (JNK) pathway in the TGF-beta 1 stimulation of urokinase-type plasminogen activator (uPA), initial stages of epithelial-mesenchymal transdifferentiation ...
Knockdown of the c-Jun-N-terminal kinase expression by siRNA inhibits MCF-7 breast carcinoma cell line growth
(2010)
We have examined the effect of two small interference RNA against Jnk-1 and Jnk-2 in the breast cancer cell line MCF-7. The expression of the JNK-1 and JNK-2 is frequently elevated in breast cancer and is a frequent genetic ...
c-jun-NH2JNK mediates invasive potential and EGFR activation by regulating the expression of HB-EGF in a urokinase-stimulated pathway
(WILEY-LISS, DIV JOHN WILEY & SONS INC, 2008-02-15)
In this study, we demonstrated that tyrosine phosphorylation of EGFR and the autocrine expression of uPA and HB-EGF depend on the activity of c-jun amino-terminal kinase (JNK) in human prostatic DU-145 cells. These cells ...
IKK connects autophagy to major stress pathways
(Taylor and Francis Inc., 2010)
Cells respond to stress by activating cytoplasmic mechanisms as well as transcriptional programs that can lead to adaptation or death. Autophagy represents an important cytoprotective response that is regulated by both ...
The role of the B7-1/2, LFA-3 and ICAM-1 costimulatory molecules in the modulation of T cell responses
(2002)
The physiological activation of T cells to proliferation and cytokine production requires at least two signals. Occupancy of the T cell receptor by antigen/MHC complexes delivers the first signal to T cell, while the second ...
Ha-Ras sensitizes transformed mouse skin cells to Anisomycin-induced apoptosis
(ELSEVIER SCIENCE BV, 2005-11-21)
Efforts have been made to develop a chemoprevention that selectively triggers apoptosis in malignant cancer cells. Here, we demonstrated that a mutated Ha-Ras activity is required in Anisomycin-induced apoptosis in transformed ...
Cigarette smoke condensate stimulates urokinase production through the generation of reactive oxygen species and activation of the mitogen activated protein kinase pathways in human gingival fibroblasts
(Blackwell Munksgaard, 2009)
Background and Objective: Tobacco smoking is a significant risk factor for periodontal disease. It has been suggested that smoking may alter connective tissue remodeling in the periodontium. In the present study, we ...
Frizzled-5 Receptor Is Involved in Neuronal Polarity and Morphogenesis of Hippocampal Neurons
(2013)
The Wnt signaling pathway plays important roles during different stages of neuronal development, including neuronal
polarization and dendritic and axonal outgrowth. However, little is known about the identity of the ...