Artículo de revista
IKK connects autophagy to major stress pathways
Fecha
2010Registro en:
Autophagy, Volumen 6, Issue 1, 2018, Pages 189-191
15548635
15548627
10.4161/auto.6.1.10818
Autor
Criollo Céspedes, Alfredo
Senovilla, Laura
Authier, Hélène
Maiuri, Maria Chiara
Morselli, Eugenia
Vitale, Ilio
Kepp, Oliver
Tasdemir, Ezgi
Galluzzi, Lorenzo
Shen, Si
Tailler, Maximilien
Delahaye, Nicolas
Tesniere, Antoine
De Stefano, Daniela
Younes, Aména Ben
Harp
Institución
Resumen
Cells respond to stress by activating cytoplasmic mechanisms as well as transcriptional programs that can lead to adaptation or death. Autophagy represents an important cytoprotective response that is regulated by both transcriptional and transcription-independent pathways. NFκB is perhaps the transcription factor most frequently activated by stress and has been ascribed with either pro- or anti-autophagic functions, depending on the cellular context. Our results demonstrate that activation of the IKK (IκB kinase) complex, which is critical for the stress-elicited activation of NFκB, is sufficient to promote autophagy independent of NFκB, and that IKK is required for the optimal induction of autophagy by both physiological and pharmacological autophagic triggers. © 2010 Landes Bioscience.