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Mostrando ítems 21-30 de 201
Silencing of the transcription factors Oct4, Sox2, Klf4, c-Myc or Nanog has different effect on teratoma growth
(Academic Press Inc Elsevier Science, 2019-07)
Induced pluripotent stem cells (iPSC) have a great potential, but their clinical application depends on finding strategies to abolish their tumorigenic potential. The use of Oct4, Sox2, Klf4, c-Myc and Nanog to generate ...
Bacterially expressed dsRNA induces Varroa destructor gene knockdown by honey bee-mediated oral administration
(Taylor and Francis, 2022-02)
The ectoparasite Varroa destructor causes serious losses of Apis mellifera colonies and negatively impacts the beekeeping industry around the world. New control methods have been proposed based on the RNA interference ...
Midgut Genes Knockdown by Oral dsRNA Administration Produces a Lethal Effect on Cotton Boll Weevil
(Springer, 2021-02)
The “cotton boll weevil” (Anthonomus grandis Boheman) is a key pest in America whose larval stage develops within the cotton flower bud. During its development, the larva uses the flower bud as food and as a shelter from ...
A Medicago truncatula rdr6 allele impairs transgene silencing and endogenous phased siRNA production but not development
(Wiley Blackwell Publishing, Inc, 2014-12)
Summary: RNA-dependent RNA polymerase 6 (RDR6) and suppressor of gene silencing 3 (SGS3) act together in post-transcriptional transgene silencing mediated by small interfering RNAs (siRNAs) and in biogenesis of various ...
Potato Snakin-1 Gene Silencing Affects Cell Division, Primary Metabolism, and Cell Wall Composition
(American Society of Plant Biologists, 2012-01)
Snakin-1 (SN1) is an antimicrobial cysteine-rich peptide isolated from potato (Solanum tuberosum) that was classified as a member of the Snakin/Gibberellic Acid Stimulated in Arabidopsis protein family. In this work, a ...
Galacturonosyltransferase 4 silencing alters pectin composition and carbon partitioning in tomato
(2013-04)
Pectin is a main component of the plant cell wall and is the most complex family of polysaccharides in nature. Its composition is essential for the normal growth and morphology pattern, as demonstrated by pectin-defective ...
TRNA genes affect chromosome structure and function via local effects
(American Society for Microbiology, 2019-04)
The genome is packaged and organized in an ordered, nonrandom manner, and specific chromatin segments contact nuclear substructures to mediate this organization. tRNA genes (tDNAs) are binding sites for transcription factors ...
HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing
(Oxford University Press, 2021-03)
HASTY, the plant ortholog of human exportin 5, was proposed to export miRNAs from the nucleus to the cytoplasm, whereas this has long been disputed. This study shows that HASTY, rather than acting as a miRNA cargo protein, ...
A Quick HYL1-Dependent Reactivation of MicroRNA Production Is Required for a Proper Developmental Response after Extended Periods of Light Deprivation
(Cell Press, 2018-07)
Achkar et al. show that a nuclear reserve pool of inactive phosphorylated HYL1, an essential cofactor for microRNA biogenesis, is resistant to dark- or shade-induced degradation. Upon light restoration, this HYL1 pool is ...
Silencing the hsp25 gene eliminates migration capability of the highly metastatic murine 4t1 breast adenocarcinoma cell
(Karger, 2005-12-08)
The 25-kDa heat shock protein (Hsp25) is associated with various malignancies and is expressed at high levels in biopsies as well as circulating in the serum of breast cancer patients. In this study, we used RNA interference ...