info:eu-repo/semantics/article

HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing

Fecha
2021-03
Registro en:
Cambiagno, Damián Alejandro; Giudicatti, Axel Joel; Arce, Agustín Lucas; Gagliardi, Delfina; Li, Lei; et al.; HASTY modulates miRNA biogenesis by linking pri-miRNA transcription and processing; Oxford University Press; Molecular Plant; 14; 3; 3-2021; 426-439
1674-2052
CONICET Digital
CONICET
Autor
Cambiagno, Damián Alejandro
Giudicatti, Axel Joel
Arce, Agustín Lucas
Gagliardi, Delfina
Li, Lei
Yuan, Wei
Lundberg, Derek S.
Weigel, Detlef
Manavella, Pablo Andrés
Institución
Resumen
HASTY, the plant ortholog of human exportin 5, was proposed to export miRNAs from the nucleus to the cytoplasm, whereas this has long been disputed. This study shows that HASTY, rather than acting as a miRNA cargo protein, promotes miRNA biogenesis by stabilizing a complex between DCL1 and Mediator at MIRNA loci, thereby acting as a linker between pri-miRNA transcription and processing.
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