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The β2-adrenergic agonist salbutamol inhibits migration, invasion and metastasis of the human breast cancer MDA-MB-231 cell line
(Bentham Science Publishers, 2017)
Background: Breast cancer is the most diagnosed and the major cause of cancer death in women worldwide. Metastasis is the main cause of these deaths. The metastatic cascade involves multiple steps and it has been described ...
Genes related to suppression of malignant phenotype induced by Maitake D-Fraction in breast cancer cells
(Mary Ann Liebert Inc, 2013-07)
It is already known that the Maitake (D-Fraction) mushroom is involved in stimulating the immune system and activating certain cells that attack cancer, including macrophages, T-cells, and natural killer cells. According ...
Revisiting progesterone receptor (PR) actions in breast cancer: Insights into PR repressive functions
(Elsevier Science Inc, 2018-05)
Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls developmental processes and proliferation and differentiation during the reproductive cycle and pregnancy. PR also plays a role ...
Pathophysiological role of histamine H4 Receptor in cancer: therapeutic implications
(Frontiers Media S.A., 2019-05)
Cancer is a leading cause of death in both developed and developing countries. Although advances in cancer research lead to improved anti-neoplastic therapies, they continue to have unfavorable outcomes, including poor ...
Thwarting galectin-induced immunosuppression in breast cancer
(Landes Biosciences, 2013-05)
Novel therapeutic strategies are needed to counteract breast cancer-associated immunosuppression. Silencing the expression of galectin-1 in a breast carcinoma model inhibited tumor growth and prevented lung metastasis by ...
Paxillin, a novel controller in the signaling of estrogen to FAK/N-WASP/Arp2/3 complex in breast cancer cells
(Elsevier Ireland, 2016-07-15)
Breast cancer is the major cause of cancer-related death in women. Its treatment is particularly difficult when metastasis occurs. The ability of cancer cells to move and invade the surrounding environment is the basis of ...
Linc00885 a novel oncogenic long non-coding rna associated with early stage breast cancer progression
(MDPI AG, 2020-10-08)
Long intergenic non-protein coding RNA 885 (LINC00885) was identified as significantly upregulated in breast ductal carcinoma in situ (DCIS). The aim of this study was to characterize the phenotypic effects and signaling ...
Prognostic significance of α‐ and β2‐adrenoceptor gene expression in breast cancer patients
(The British Pharmacological Society, 2019-07)
Breast cancer is the most frequently diagnosed and leading cause of cancer death among women worldwide. It was classified within molecular intrinsic subtypes: luminal A, luminal B, human epidermal growth factor receptor ...
Alternative splicing variant of RHBDD2 is associated with cell stress response and breast cancer progression
(Spandidos Publications, 2018-08)
RHBDD2 is an intramembrane pseudoprotease member of the Rhomboid superfamily. Our previous studies in breast and colorectal cancer indicate an association between RHBDD2 overexpression and advanced tumor stages. Two ...
Therapeutic opportunities for PLK1 inhibitors: Spotlight on BRCA1-deficiency and triple negative breast cancers
(Elsevier Science, 2020-05)
Polo-Like Kinases (PLKs) are central players of mitotic progression in Eukaryotes. Given the intimate relationship between cell cycle progression and cancer development, PLKs in general and PLK1 in particular have been ...