info:eu-repo/semantics/article
Thwarting galectin-induced immunosuppression in breast cancer
Fecha
2013-05Registro en:
Salatino, Mariana; D'alotto Moreno, Tomas; Rabinovich, Gabriel Adrián; Thwarting galectin-induced immunosuppression in breast cancer; Landes Biosciences; OncoImmunology; 2; 5; 5-2013; 24077-24079
2162-402X
CONICET Digital
CONICET
Autor
Salatino, Mariana
D'alotto Moreno, Tomas
Rabinovich, Gabriel Adrián
Resumen
Novel therapeutic strategies are needed to counteract breast cancer-associated immunosuppression. Silencing the expression of galectin-1 in a breast carcinoma model inhibited tumor growth and prevented lung metastasis by reducing the frequency and immunosuppressive activity of CD4+CD25+ FOXP3+ regulatory T cells