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Naltrexone effects on insulin sensitivity and insulin secretion in hyperandrogenic women
(1998)
A total of 12 women (24.2 ± 1.6 years old, BMI 36.7 ± 1.5 Kg/m2) with hyperandrogenism (HA) and with normal glucose tolerance test were studied to evaluate the involvement of endogenous opioids in the pathophysiology of ...
Previous administration of naltrexone did not change synergism between paracetamol and tramadol in mice
(2012)
In the treatment of acute and chronic pain the most frequently used drugs are nonsteroidal anti-inflammatory drugs (NSAIDs), e.g., paracetamol; opioids, e.g., tramadol, and a group of drugs called coanalgesics or adjuvants ...
Opiate antagonist treatment of ovarian failure
(1993)
One-hundred-and-thirty-eight women suffering from hypothalamicor hyperandrogenic ovarian failure were treatedwith daily doses of 25-150 mg of the opiate antagonist naltrexone for 4-100 weeks.In patients with hypothalamicovarian ...
Evidence that Melanocortin Receptor Agonist Melanotan-II Synergistically Augments the Ability of Naltrexone to Blunt Binge-Like Ethanol Intake in Male C57BL/6J Mice
(Blackwell, 2015)
Background—The non-selective opioid receptor antagonist, naltrexone (NAL), reduces alcohol (ethanol) consumption in animals and humans and is an approved medication for treating alcohol abuse disorders. Proopiomelanocortin ...
Involvement of nitridergic and opioidergic pathways in the antinociception of gabapentin in the orofacial formalin test in mice
(Elsevier, 2015)
Background: Pain is one of the most common problems in clinical medicine. There is considerable
evidence that pharmacologic approaches are the most widely used therapeutic options to ameliorate
persistent or chronic pain. ...
Lack of effect of naltrexone on the spinal synergism between morphine and non steroidal anti-inflammatory drugs
(Polish Academy of Sciences, 2009)
To enhance analgesia, the combinatorial use of analgesic drugs with proven efficacies is a widely-used strategy to reduce adverse side effects. The present study characterizes the antinociceptive interaction of intrathecal ...
Salsolinol, free of isosalsolinol, exerts ethanol-like motivational/sensitization effects leading to increases in ethanol intake
(Elsevier Inc., 2014)
© 2014 Elsevier Inc.Salsolinol is formed non-enzymatically when ethanol-derived acetaldehyde binds to dopamine, yielding 2 distinct products, i.e., salsolinol and isosalsolinol. Early animal studies, revealing that salsolinol ...
Synergy between the antinociceptive effects of morphine and NSAIDs
(2004)
The intraperitoneal administration of morphine, diclofenac, ketoprofen, meloxicam, metamizol, paracetamol and piroxicam induced dose-dependent antinociception in mice tested with the acetic acid writhing test. The ...
The effect of opioid antagonists on synergism between dexketoprofen and tramadol
(2009)
The antinociceptive activity of dexketoprofen was studied in mice using the formalin assay for orofacial pain. The interaction between dexketoprofen and co-administered tramadol was studied using isobolographic analysis. ...
Isobolographic analysis of the opioid-opioid interactions in a tonic and a phasic mouse model of induced nociceptive pain
(BioMed Central, 2014)
Background: Opioids have been used for the management of pain and coadministration of two opioids may
induce synergism. In a model of tonic pain, the acetic acid writhing test and in a phasic model, the hot plate, ...