Artículo de revista
Involvement of nitridergic and opioidergic pathways in the antinociception of gabapentin in the orofacial formalin test in mice
Fecha
2015Registro en:
Pharmacological Reports 67 (2015) 399–403
Doi.org/10.1016/j.pharep.2014.10.018
Autor
Miranda, Hugo
Sierralta, Fernando
Lux, Sebastian
Troncoso, Rocío
Ciudad, Natalia
Zepeda Iriarte, Ramiro
Zanetta, Pilar
Noriega, Viviana
Prieto, Juan Carlos
Institución
Resumen
Background: Pain is one of the most common problems in clinical medicine. There is considerable
evidence that pharmacologic approaches are the most widely used therapeutic options to ameliorate
persistent or chronic pain. In this study it was evaluated the effect of L-NAME and naltrexone in the
antinociception induced by administration of gabapentin in the orofacial formalin test of mice.
Methods: The algesiometer assay was performed by the administration of 20 ml of 2% formalin solution
injected into the upper right lip of each mouse.
Results: The dose of gabapentin that produces the 50% of the maximum possible effect (ED50) was
significantly increased by the pretreatment with L-NAME or naltrexone.
Conclusions: These results suggest that gabapentin produce antinociception partly via the activation
nitridergic pathways and opioid system.