Artículo de revista
Previous administration of naltrexone did not change synergism between paracetamol and tramadol in mice
Fecha
2012Registro en:
Pharmacology Biochemistry and Behavior, Volumen 102, Issue 1, 2018, Pages 72-76
00913057
18735177
10.1016/j.pbb.2012.03.008
Autor
Miranda, Hugo F.
Noriega, Viviana
Prieto, Juan Carlos
Institución
Resumen
In the treatment of acute and chronic pain the most frequently used drugs are nonsteroidal anti-inflammatory drugs (NSAIDs), e.g., paracetamol; opioids, e.g., tramadol, and a group of drugs called coanalgesics or adjuvants (e.g., antidepressants, anticonvulsants). The aim of this work was to determine the nature of the interaction induced by intraperitoneal or intrathecal coadministration of paracetamol and tramadol. The type of interaction was evaluated by means of isobolographic analysis, using the acetic acid writhing test as an algesiometer in mice. In addition, the involvement of opioid receptors in the interaction was studied using naltrexone, a non-selective opioid receptor antagonist. The administration of paracetamol or tramadol induced a dose-dependent antinociceptive activity in the assay. The dose-response curves were characterized by equal efficacy but different potencies, being i.t. paracetamol 11.84 times more potent than i.p. paracetamol, and i.t. tramadol 3.54 times mo