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Prenatal hyperandrogenism induces alterations that affect liver lipid metabolism
(Society for Endocrinology, 2016-07-01)
Prenatal hyperandrogenism is hypothesized as one of the main factors contributing to26 the development of polycystic ovary syndrome (PCOS). PCOS patients have high risk27 of developing fatty liver and steatosis. This study ...
Effect of hyperandrogenism on ovarian function
(BioScientifica, 2015-06)
The objective of the present work was to study the ovarian function when follicular development is induced during a hyperandrogenic condition. Female rats were injected either with chorionic gonadotropin (eCG group) to ...
Increased chemerin serum levels in hyperandrogenic and normoandrogenic women from Argentina with polycystic ovary syndrome
(Informa Healthcare, 2020-06)
Aim: To assess serum chemerin levels and investigate the association of chemerin with the hyperandrogenic and normoandrogenic phenotypes of Polycystic Ovary Syndrome (PCOS) and with the metabolic status of the analyzed ...
Prenatal testosterone exposure induces insulin resistance, uterine oxidative stress and pro-inflammatory status in rats
(Elsevier Ireland, 2020-01)
Prenatal androgen excess is considered one of the main causes of the development of polycystic ovary syndrome. In this study, we investigated the effect of prenatal hyperandrogenization (PH) on the physiology of the adult ...
Fetal programming by androgen excess in rats affects ovarian fuel sensors and steroidogenesis
(Cambridge University Press, 2019-02)
Fetal programming by androgen excess is hypothesized as one of the main factors contributing to the development of polycystic ovary syndrome (PCOS). PCOS is more than a reproductive disorder, as women with PCOS also show ...
Metformin improves ovarian insulin signaling alterations caused by fetal programming
(BioScientifica, 2019-03)
Insulin resistance is the decreased ability of insulin to mediate metabolic actions. In the ovary, insulin controls ovulation and oocyte quality. Alterations in ovarian insulin signaling pathway could compromise ovarian ...
Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice
(Elsevier Science Inc, 2011-06)
Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor γ (PPARγ) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPARγ is not modified, but the gene and protein ...