Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice

Elia, Evelin Mariel; Pustovrh, María Carolina; Amalfi, Sabrina; Devoto, Luigi; Motta, Alicia Beatriz

info:eu-repo/semantics/article

Fecha

2011-06

Registro en:

Elia, Evelin Mariel; Pustovrh, María Carolina; Amalfi, Sabrina; Devoto, Luigi; Motta, Alicia Beatriz; Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice; Elsevier Science Inc; Fertility and Sterility; 95; 8; 6-2011; 1-5

0015-0282

http://hdl.handle.net/11336/67730

CONICET Digital

CONICET

https://repositorioslatinoamericanos.uchile.cl/handle/2250/4320018

Autor

Elia, Evelin Mariel

Pustovrh, María Carolina

Amalfi, Sabrina

Devoto, Luigi

Motta, Alicia Beatriz

Institución

Consejo Nacional de Investigaciones Científicas y Tecnológicas (Argentina)

Resumen

Chronic hyperandrogenism alters the peroxisome proliferator-activated receptor γ (PPARγ) pathway in the uterine tissue of prepubertal mice. The gene and protein expression of PPARγ is not modified, but the gene and protein expression of 12-lipoxygenase (12-LOX), an enzyme that synthesizes PPARγ ligands, is decreased. The antihyperglycemic drug metformin can prevent this adverse effect.

Materias

Lipoxygenases

Metformin

Peroxisome Proliferator Activated Receptor Gamma

Polycystic Ovary Syndrome

Uterus

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