info:eu-repo/semantics/article
Prenatal hyperandrogenism induces alterations that affect liver lipid metabolism
Fecha
2016-07-01Registro en:
Abruzzese, Giselle Adriana; Heber, María Florencia; Ferreira, Silvana Rocío; Velez, Leandro Martin; Reynoso, Roxana María; et al.; Prenatal hyperandrogenism induces alterations that affect liver lipid metabolism; Society for Endocrinology; Journal of Endocrinology; 230; 1-7-2016; 67-79
0022-0795
1479-6805
CONICET Digital
CONICET
Autor
Abruzzese, Giselle Adriana
Heber, María Florencia
Ferreira, Silvana Rocío
Velez, Leandro Martin
Reynoso, Roxana María
Pignataro, Omar Pedro
Motta, Alicia Beatriz
Resumen
Prenatal hyperandrogenism is hypothesized as one of the main factors contributing to26 the development of polycystic ovary syndrome (PCOS). PCOS patients have high risk27 of developing fatty liver and steatosis. This study aimed to evaluate the role of prenatal28 hyperandrogenism in liver lipid metabolism and fatty liver development. Pregnant rats29 were hyperandrogenized with testosterone. At pubertal age, the prenatally30 hyperandrogenized (PH) female offspring displayed both ovulatory (PHov) and31 anovulatory (PHanov) phenotypes that mimic human PCOS features. We evaluated32 hepatic transferases, liver lipid content, the balance between lipogenesis and fatty acid33 oxidation pathway, oxidant/antioxidant balance and pro-inflammatory status. We also34 evaluated the general metabolic status through growth rate curve, basal glucose and35 insulin levels, glucose tolerance test, HOMA-IR index and serum lipid profile.36 Although neither PH group showed signs of liver lipid content, the lipogenesis and fatty37 oxidation pathways were altered. The PH groups also showed impaired38 oxidant/antioxidant balance, a decrease in the pro-inflammatory pathway (measured by39 prostaglandin E2 and cyclooxygenase-2 levels), decreased glucose tolerance, imbalance40 of circulating lipids and increased risk of metabolic syndrome. We conclude that41 prenatal hyperandrogenism generates both PHov and PHanov phenotypes with signs of42 liver alterations, imbalance in lipid metabolism and increased risk of developing43 metabolic syndrome. The anovulatory phenotype showed more alterations in liver44 lipogenesis and a more impaired balance of insulin and glucose metabolism, being more45 susceptible to the development of steatosis.