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Requirement for Ergosterol in V-ATPase Function Underlies Antifungal Activity of Azole Drugs
(Public Library of Science, 2010-06)
Ergosterol is an important constituent of fungal membranes. Azoles inhibit ergosterol biosynthesis, although the cellular basis for their antifungal activity is not understood. We used multiple approaches to demonstrate a ...
Synergistic antifungal activity of statin-azole associations as witnessed by Saccharomyces cerevisiae- and Candida utilis-bioassays and ergosterol quantificationActividad antifúngica sinérgica de combinaciones de estatinas y azólicos revelada mediante bioanálisis con Saccharomyces cerevisiae y Candida utilis y cuantificación de ergosterol
(Asociacion Española Micología, 2013-01-03)
Background: Frequent opportunist fungal infections and the resistance to available antifungal drugs promoted the development of new alternatives for treatment, like antifungal drug combinations. Aims: This work aimed to ...
The cytochrome b(5) dependent C-5(6) sterol desaturase DES5A from the endoplasmic reticulum of Tetrahymena thermophila complements ergosterol biosynthesis mutants in Saccharomyces cerevisiae.
(Elsevier Science Inc, 2012-09)
Tetrahymena thermophila is a free-living ciliate with no exogenous sterol requirement. However, it can perform several modifications on externally added sterols including desaturation at C5(6), C7(8), and C22(23). Sterol ...
Comparative Efficacies of TAK-187, a Long-Lasting Ergosterol Biosynthesis Inhibitor, and Benznidazole in Preventing Cardiac Damage in a Murine Model of Chagas' Disease
(American Society for Microbiology, 2005-03)
We carried out a comparative study of benznidazole and TAK-187, a long-lasting ergosterol biosynthesis inhibitor, with a murine model of Chagas` disease. The results indicated that TAK-187 was more effective than benznidazole ...
Síntesis y caracterización del 3b-tetrahidroxipiraniloxi23,24-bisnor-5-coleno-22-malonamida, intermediario clave para la síntesis de nuevos azasteroles
(Facultad Experimental de Ciencias de la Universidad del Zulia, 2015)
Mycorrhizal fungal biomass and scavenging declines in phosphorus-impoverished soils during ecosystem retrogression
(Pergamon-Elsevier Science Ltd, 2016-01)
Mycorrhizal fungi enhance plant phosphorus (P) acquisition via their extraradical hyphae (ERH) that scavenge nutrients outside root depletion zones. While soil P availability declines during ecosystem retrogression, how ...