info:eu-repo/semantics/article
Comparative Efficacies of TAK-187, a Long-Lasting Ergosterol Biosynthesis Inhibitor, and Benznidazole in Preventing Cardiac Damage in a Murine Model of Chagas' Disease
Fecha
2005-03Registro en:
Corrales, Milagros; Cardozo, Rubén Marino; Segura, Maria Asuncion; Urbina, Julio A.; Basombrío, Miguel Ángel Manuel; Comparative Efficacies of TAK-187, a Long-Lasting Ergosterol Biosynthesis Inhibitor, and Benznidazole in Preventing Cardiac Damage in a Murine Model of Chagas' Disease; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 49; 4; 3-2005; 1556-1560
0066-4804
CONICET Digital
CONICET
Autor
Corrales, Milagros
Cardozo, Rubén Marino
Segura, Maria Asuncion
Urbina, Julio A.
Basombrío, Miguel Ángel Manuel
Resumen
We carried out a comparative study of benznidazole and TAK-187, a long-lasting ergosterol biosynthesis inhibitor, with a murine model of Chagas` disease. The results indicated that TAK-187 was more effective than benznidazole in preventing Trypanosoma cruzi-induced cardiac damage in experimental animals.