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Structural antitumoral activity relationships of synthetic chalcones
(2009)
Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2'-hydroxychalcones resulted in apoptosis induction ...
Síntesis y estudio de la actividad antitumoral y antituberculosa de análogos anticíclicos enónicos derivados del pirazol.
(2011-10-14)
Se ha sintetizado una serie de derivados enónicos del tipo (E)-3-(1-aril-5-cloro-3-metil-1H-pirazol-4-il)-1-fenilprop-2-en-1-ona 6 y (1E)-N,N-dimetil-N'-(3-metil-4-((E)-3-oxo-3-fenilpop-1-enil)-1-aril-1-H-pirazol-5-il)formamidine ...
Antitumor activity and carrier properties of novel hemocyanins coupled to a mimotope of GD2 ganglioside
(Elsevier, 2018-04-25)
Conjugation to carrier proteins is a way to improve the immunogenicity of peptides. Such is the case for peptides mimicking carbohydrate tumor-associated antigens in cancer vaccine development. The most used protein for ...
Molecular docking studies of the antitumoral activity and characterization of new chalcone
(Bentham Science Publishers B.V., 2015)
© 2015, Bentham Science Publishers.Phytochemical investigation of Azorella madreporica led to the isolation of four known compounds and an unknown chalcone. The structure of the new compound was identified by spectroscopy, ...
Potential use of nanocarriers with pentacyclic triterpenes in cancer treatments
(Future Medicine Ltd, 2016-12)
Ursolic, oleanolic and betulinic acids are representative pentacyclic triterpenoids found in various plants and fruits. Despite having marked antitumor potentials, the very poor water solubility of these triterpenes hinders ...
Citotoxixity antitumor effect and phitochemical screening of cucumis dipsaceus
(Revista Colombiana de Ciencias Químico Farmacéuticas, 1999)
The results of the present work showed a high cytotoxic percentage against the human tumoral cellular lines K562 and Hep-2 of the ethanolic extracts of the fruits and of the shafts with leaves of Cucumis dipsaceus. The ...
Biological evaluation of novel 6-arylbenzimidazo [1,2-c]quinazoline derivatives as inhibitors of LPS-induced TNF-alpha secretion
(SOC BIOLGIA CHILE, 2008)
This study describes the effect of novel 6-Arylbenzimidazo[1,2-c]quinazoline derivatives as tumor necrosis factor alpha (TNF-alpha) production inhibitors. The newly synthesized compounds were tested for their in vitro ...
Cyclodextrin Nanosponges Inclusion Compounds Associated with Gold Nanoparticles for Potential Application in the Photothermal Release of Melphalan and Cytoxan
(MDPI, 2021)
This article describes the synthesis and characterization of beta-cyclodextrin-based nano-sponges (NS) inclusion compounds (IC) with the anti-tumor drugs melphalan (MPH) and cytoxan (CYT), and the addition of gold nanoparticles ...
Human CD1d knock-in mouse model demonstrates potent antitumor potential of human CD1d-restricted invariant natural killer T cells
(NATL ACAD SCIENCES, 2012-12-04)
Despite a high degree of conservation, subtle but important differences exist between the CD1d antigen presentation pathways of humans and mice. These differences may account for the minimal success of natural killer T ...
Dead tumor cells expressing infectious salmon anemia virus fusogenic protein favor antigen cross-priming in vitro
(Frontiers media SA, 2017)
Antigen cross-presentation is a crucial step in the assembly of an antitumor immune response leading to activation of naive CD8 T cells. This process has been extensively used in clinical trials, in which dendritic cells ...