Artículo de revista
Structural antitumoral activity relationships of synthetic chalcones
Fecha
2009Registro en:
International Journal of Molecular Sciences, 2009, 10, 221-231
14220067
10.3390/ijms10010221
Autor
Echeverría, César
Santibáñez, Juan Francisco
Donoso Tauda, Óscar
Escobar, Carlos A.
Ramírez Tagle, Rodrigo
Institución
Resumen
Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2'-hydroxychalcones resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated reactivity indexes and the adiabatic electron affinities using the DFT method including solvent effects, suggest a structure-activity relationship between the Chalcones structure and the apoptosis in HepG2 cells. The absence of methoxy substituents in the B ring of synthetic 2'-hydroxychalcones, showed the mayor structure-activity pattern along the series.