Artículo de revista
Biological evaluation of novel 6-arylbenzimidazo [1,2-c]quinazoline derivatives as inhibitors of LPS-induced TNF-alpha secretion
Fecha
2008Registro en:
BIOLOGICAL RESEARCH Volume: 41 Issue: 1 Pages: 43-50 Published: 2008
0716-9760
Autor
Galarce, Gloria D.
Foncea, Rocío
Edwards, Ana María
Pessoa Mahana, Hernán
Pessoa Mahana, Carlos David
Ebensperger González, Roberto
Institución
Resumen
This study describes the effect of novel 6-Arylbenzimidazo[1,2-c]quinazoline derivatives as tumor necrosis factor alpha (TNF-alpha) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-alpha secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo[1,2-c]quinazoline, coded as G1, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo[1,2-c]quinazoline derivatives may have a potential as anti-inflammatory agents.