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Synthetic inhibitors of galectin-1 and -3 selectively modulate homotypic cell aggregation and tumor cell apoptosis
(Int Inst Anticancer Research, 2009)
Galectins have emerged as critical regulators of tumor progression and metastasis, by modulating different biological events including homotypic cell aggregation, apoptosis, migration, angiogenesis and immune escape. ...
Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
(Nature Publishing Group, 2009-12)
Despite their central function in orchestrating immunity, dendritic cells (DCs) can respond to inhibitory signals by becoming tolerogenic. Here we show that galectin-1, an endogenous glycan-binding protein, can endow DCs ...
Thwarting galectin-induced immunosuppression in breast cancer
(Landes Biosciences, 2013-05)
Novel therapeutic strategies are needed to counteract breast cancer-associated immunosuppression. Silencing the expression of galectin-1 in a breast carcinoma model inhibited tumor growth and prevented lung metastasis by ...
Full-length galectin-8 and separate carbohydrate recognition domains: the whole is greater than the sum of its parts?
(Portland Press, 2020-06)
Galectin-8 (Gal-8) is a tandem-repeat type galectin with affinity for β-galactosides, bearing two carbohydrate recognition domains (CRD) connected by a linker peptide. The N- and C-terminal domains (Gal-8N and Gal-8C) share ...
Stable and high expression of Galectin-8 tightly controls metastatic progression of prostate cancer
(Impact Journals LLC, 2017-03)
Two decades ago, Galectin-8 was described as a prostate carcinoma biomarker since it is only expressed in the neoplastic prostate, but not in the healthy tissue. To date, no biological function has been attributed to ...
Glycans and galectins in prostate cancer biology, angiogenesis and metastasis
(Oxford University Press, 2014-06)
Prostate cancer is the second most common cause of cancer and the sixth leading cause of cancer death among men worldwide. While localized prostate cancer can be cured, advanced and metastatic prostate cancer remains a ...
Study of galectins in tumor immunity: strategies and methods.
(Springer, 2015-01)
During the past decade, a better understanding of the cellular and molecular mechanisms underlying tumor immunity has provided the appropriate framework for the development of therapeutic strategies for cancer immunotherapy. ...
Role of galectin-glycan circuits in reproduction: from healthy pregnancy to preterm birth (PTB)
(Springer, 2020-08)
Growing evidence suggests that galectins, an evolutionarily conserved family of glycan-binding proteins, fulfill key roles in pregnancy including blastocyst implantation, maternal-fetal immune tolerance, placental development, ...
Galectin-1 induces 12/15-lipoxygenase expression in murine macrophages and favors their conversion toward a pro-resolving phenotype
(Elsevier Science Inc, 2013-08-14)
During the resolution of inflammation macrophages undergo functional changes upon exposure to pro-resolving agents in their microenvironment. Primarily, engulfment of apoptotic polymorphonuclear (PMN) cells promotes ...
Human recombinant galectin-1 produced by transplantomic tabacco plants
(Tech Science Press, 2019)
Transplastomic plants stand out from other molecular farming platforms because of the highly efficient production of recombinant proteins(>50% of the total soluble protein). In some cases, however, low and even undetectable ...