info:eu-repo/semantics/article
Study of galectins in tumor immunity: strategies and methods.
Date
2015-01Registration in:
Cerliani, Juan Pablo; D'alotto Moreno, Tomas; Compagno, Daniel Georges; Dergan Dylon, Leonardo Sebastian; Laderach, Diego Jose; et al.; Study of galectins in tumor immunity: strategies and methods.; Springer; Methods in Molecular Biology; 1207; 1-2015; 249-268
978-1-4939-1395-4
1064-3745
1940-6029
Author
Cerliani, Juan Pablo
D'alotto Moreno, Tomas
Compagno, Daniel Georges
Dergan Dylon, Leonardo Sebastian
Laderach, Diego Jose
Gentilini, Lucas Daniel
Croci Russo, Diego Omar
Mendez Huergo, Santiago Patricio
Toscano, Marta Alicia
Salatino, Mariana
Rabinovich, Gabriel Adrian
Abstract
During the past decade, a better understanding of the cellular and molecular mechanisms underlying tumor immunity has provided the appropriate framework for the development of therapeutic strategies for cancer immunotherapy. Under this complex scenario, galectins have emerged as promising molecular targets for cancer therapy responsible of creating immunosuppressive microenvironments at sites of tumor growth and metastasis. Galectins, expressed in tumor, stromal, and endothelial cells, contribute to thwart the development of immune responses by favoring the expansion of T regulatory cells and contributing to their immunosuppressive activity, driving the differentiation of tolerogenic dendritic cells, limiting T cell viability, and maintaining T cell anergy. The emerging data promise a future scenario in which the selective blockade of individual members of the galectin family, either alone or in combination with other therapeutic regimens, will contribute to halt tumor progression by counteracting tumor-immune escape. Here we describe a selection of methods used to investigate the role of galectin-1 in tumor-immune escape.