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Galectins in intestinal inflammation: Galectin-1 expression delineates response to treatment in celiac disease patients
(Frontiers Media S.A., 2018-03)
Galectins, a family of animal lectins characterized by their affinity for N-acetyllactosamine-enriched glycoconjugates, modulate several immune cell processes shaping the course of innate and adaptive immune responses. ...
The Role of Galectin-3 and ST2 in Cardiology: A Short Review
(Molecular Diversity Preservation International, 2021-08)
Galectin-3 is a lectin that binds beta-galactosides. It is involved in cardiac remodeling and fibrosis through the activation of macrophages and fibroblasts. ST2 is secreted by myocardial cells due to cardiac overload. ...
Galectins: Key players in the tumor microenvironment
(Elsevier, 2013)
Galectins are glycan‐binding proteins implicated in several biological activities such as intracellular signaling, cell‐cell communication, cellular proliferation and survival. These endogenous lectins have emerged as key ...
Delineating the "galectin signature" of the tumor microenvironment
(Landes Bioscience, 2013-04)
Galectins, a family of glycan-binding proteins, can control tumor progression by promoting transformation, angiogenesis and immune escape. We identified a dynamically regulated 'galectin signature', which delineates the ...
Untangling galectin-driven regulatory circuits in autoimmune inflammation
(Elsevier, 2018-04)
Although significant progress has been made in understanding the mechanisms implicated in the pathogenesis and resolution of autoimmune inflammation, studies aimed at identifying mediators of these pathways are necessary ...
Clinical relevance of galectin-1 and galectin-3 in rheumatoid arthritis patients: Differential regulation and correlation with disease activity
(Frontiers Media S.A., 2019-01)
Galectins, a family of animal lectins, play central roles in immune system regulation, shaping both innate and adaptive responses in physiological and pathological processes. These include rheumatoid arthritis (RA), a ...
Macrophages and galectin 3 play critical roles in CVB3-induced murine acute myocarditis and chronic fibrosis
(Academic Press Ltd - Elsevier Science Ltd, 2015-08)
Macrophage influx and galectin 3 production have been suggested as major players driving acute inflammation and chronic fibrosis in many diseases. However, their involvement in the pathogenesis of viral myocarditis and ...
Pregnancy galectinology: Insights into a complex network of glycan binding proteins
(Frontiers Media S.A., 2019-05)
Galectins are a phylogenetically conserved family of soluble β-galactoside binding proteins, consisting of 15 different types, each with a specific function. Galectins contribute to placentation by regulating trophoblast ...
Sweetening the hallmarks of cancer: Galectins as multifunctional mediators of tumor progression
(Rockefeller University Press, 2020-02)
Hanahan and Weinberg have proposed 10 organizing principles that enable growth and metastatic dissemination of cancer cells. These distinctive and complementary capabilities, defined as the “hallmarks of cancer,” include ...
The Structural Biology of Galectin-Ligand Recognition: Current Advances in Modeling Tools, Protein Engineering, and Inhibitor Design
(Frontiers Media S.A., 2019-12)
Galectins (formerly known as “S-type lectins”) are a subfamily of soluble proteins that typically bind β-galactoside carbohydrates with high specificity. They are present in many forms of life, from nematodes and fungi to ...