artículo
Studies on quinones. Part 42: Synthesis of furylquinone and hydroquinones with antiproliferative activity against human tumor cell lines
Fecha
2008Registro en:
10.1016/j.bmc.2007.10.028
1464-3391
0968-0896
MEDLINE:17964791
WOS:000253581500026
Autor
Benites, Julio
Valderrama, Jaime A.
Rivera, Felipe
Rojo, Leonel
Campos, Nair
Pedro, Madalena
Jose Nascimento, Maria Saeo
Institución
Resumen
The preparation of furyl-1,4-quinone and hydroquinones by reaction of 2-furaldehyde N,N-dimethylhydrazone with benzo- and naphthoquinones is reported. Access to furylnaphthoquinones from unactivated quinones requires acid-induced conditions, however oxidative coupling reactions of activated quinones proceed under neutral conditions. The in vitro cytotoxic activity of the prepared compounds against a panel of three human cancer cell lines has been studied. Most of the furyl-1,4-quinones exhibited good antiproliferative activity (GI(50) = 6.5-33.5 mu m) against the MCF-7, NCI-H460, and SF-268 (CNS cancer) cell lines chosen for testing. (C) 2007 Elsevier Ltd. All rights reserved.