Studies on quinones. Part 42: Synthesis of furylquinone and hydroquinones with antiproliferative activity against human tumor cell lines

dc.creatorBenites, Julio
dc.creatorValderrama, Jaime A.
dc.creatorRivera, Felipe
dc.creatorRojo, Leonel
dc.creatorCampos, Nair
dc.creatorPedro, Madalena
dc.creatorJose Nascimento, Maria Saeo
dc.date.accessioned2024-01-10T13:43:39Z
dc.date.accessioned2024-05-02T17:49:41Z
dc.date.available2024-01-10T13:43:39Z
dc.date.available2024-05-02T17:49:41Z
dc.date.created2024-01-10T13:43:39Z
dc.date.issued2008
dc.identifier10.1016/j.bmc.2007.10.028
dc.identifier1464-3391
dc.identifier0968-0896
dc.identifierMEDLINE:17964791
dc.identifierhttps://doi.org/10.1016/j.bmc.2007.10.028
dc.identifierhttps://repositorio.uc.cl/handle/11534/78715
dc.identifierWOS:000253581500026
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/9269103
dc.description.abstractThe preparation of furyl-1,4-quinone and hydroquinones by reaction of 2-furaldehyde N,N-dimethylhydrazone with benzo- and naphthoquinones is reported. Access to furylnaphthoquinones from unactivated quinones requires acid-induced conditions, however oxidative coupling reactions of activated quinones proceed under neutral conditions. The in vitro cytotoxic activity of the prepared compounds against a panel of three human cancer cell lines has been studied. Most of the furyl-1,4-quinones exhibited good antiproliferative activity (GI(50) = 6.5-33.5 mu m) against the MCF-7, NCI-H460, and SF-268 (CNS cancer) cell lines chosen for testing. (C) 2007 Elsevier Ltd. All rights reserved.
dc.languageen
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.rightsacceso restringido
dc.subjectquinones
dc.subjectMichael addition
dc.subjectoxidative coupling
dc.subjectcytotoxicity
dc.subjectLEISHMANICIDAL ACTIVITY
dc.subjectCYTOTOXICITY
dc.titleStudies on quinones. Part 42: Synthesis of furylquinone and hydroquinones with antiproliferative activity against human tumor cell lines
dc.typeartículo


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