Article
Impact of gut-peripheral nervous system axis on the development of diabetic neuropathy
Registro en:
OLIVEIRA, Thalita Mázala de; Sá, Yago Amigo Pinho Jannini de; Carvalho, Vinicius de Frias. Impact of gut-peripheral nervous system axis on the development of diabetic neuropathy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 118, e220197, p. 1-10, Feb. 2023.
0074-0206
10.1590/0074-02760220197
Autor
Oliveira, Thalita Mázala de
Sá, Yago Amigo Pinho Jannini de
Carvalho, Vinicius de Frias
Resumen
Diabetes is a chronic metabolic disease caused by a reduction in the production and/or action of insulin, with consequent development of hyperglycemia. Diabetic patients, especially those who develop neuropathy, presented dysbiosis, with an increase in the proportion of pathogenic bacteria and a decrease in the butyrate-producing bacteria. Due to this dysbiosis, diabetic patients presented a weakness of the intestinal permeability barrier and high bacterial product translocation to the bloodstream, in parallel to a high circulating levels of pro-inflammatory cytokines such as TNF-α. In this context, we propose here that dysbiosis-induced increased systemic levels of bacterial products, like lipopolysaccharide (LPS), leads to an increase in the production of pro-inflammatory cytokines, including TNF-α, by Schwann cells and spinal cord of diabetics, being crucial for the development of neuropathy.