Impact of gut-peripheral nervous system axis on the development of diabetic neuropathy

dc.creatorOliveira, Thalita Mázala de
dc.creatorSá, Yago Amigo Pinho Jannini de
dc.creatorCarvalho, Vinicius de Frias
dc.date2023-03-03T18:42:51Z
dc.date2023-03-03T18:42:51Z
dc.date2023
dc.date.accessioned2023-09-26T22:31:17Z
dc.date.available2023-09-26T22:31:17Z
dc.identifierOLIVEIRA, Thalita Mázala de; Sá, Yago Amigo Pinho Jannini de; Carvalho, Vinicius de Frias. Impact of gut-peripheral nervous system axis on the development of diabetic neuropathy. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 118, e220197, p. 1-10, Feb. 2023.
dc.identifier0074-0206
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/57242
dc.identifier10.1590/0074-02760220197
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8880284
dc.descriptionDiabetes is a chronic metabolic disease caused by a reduction in the production and/or action of insulin, with consequent development of hyperglycemia. Diabetic patients, especially those who develop neuropathy, presented dysbiosis, with an increase in the proportion of pathogenic bacteria and a decrease in the butyrate-producing bacteria. Due to this dysbiosis, diabetic patients presented a weakness of the intestinal permeability barrier and high bacterial product translocation to the bloodstream, in parallel to a high circulating levels of pro-inflammatory cytokines such as TNF-α. In this context, we propose here that dysbiosis-induced increased systemic levels of bacterial products, like lipopolysaccharide (LPS), leads to an increase in the production of pro-inflammatory cytokines, including TNF-α, by Schwann cells and spinal cord of diabetics, being crucial for the development of neuropathy.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFiocruz/IOC
dc.rightsopen access
dc.subjectDiabetes
dc.subjectDisbiose
dc.subjectMicrobiota intestinal
dc.subjectInflamação
dc.subjectNeuropatia
dc.subjectDiabetes
dc.subjectDysbiosis
dc.subjectGut microbiota
dc.subjectInflammation
dc.subjectNeuropathy
dc.titleImpact of gut-peripheral nervous system axis on the development of diabetic neuropathy
dc.typeArticle


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