Four experimental diets were formulated with 50, 100, 150 and 200 mg of phenolic compounds (PCs) kg-1 feed, derived from mango peel. The control diet did not contain PCs. A total of 120 male zebrafish (Danio rerio) (average weight: 166 mg) were fed for eight weeks to assess the ability of PCs to prevent lipid peroxidation and enhance antioxidant status. Growth performance was calculated at the end of the experimental trial. Lipid peroxidations in muscle and antioxidant enzyme activity in the liver were evaluated at the end of the experiment. There was no significant difference in growth performance among treatments. Malondialdehyde (MDA) levels in muscle were significantly lower in fish fed diets containing 50 and 100 mg of PCs per kg of feed. Incorporation of PCs into zebrafish diet did not have any significant effects on glutathione peroxidase and superoxide dismutase activity. However, catalase (CAT) activity increased significantly in fish with diets containing 100, 150 and 200 mg of PCs kg-1 feed. These results suggest a potential protective effect against in vivo lipid peroxidation and CAT-modulating effects.Four experimental diets were formulated with 50, 100, 150 and 200 mg of phenolic compounds (PCs), derived from mango peel, per kg of feed. The control diet did not contains PCs. A total of 120 male zebrafish (average weight: 166 mg) were fed for 8 weeks to assess the ability of PCs to prevent lipid peroxidation and enhance antioxidant status. Growth performance was calculated at the end of the experimental trial. Lipid peroxidation in muscle and antioxidant enzyme activity in liver were evaluated at the end of the experiment. There was no significant difference in growth performance among treatments. Malondialdehyde (MDA) levels in muscle were significantly lower in fish with diets containing 50 and 100 mg PCs per kg of feed. Incorporation of PCs into zebrafish diet did not have any significant effects on glutathione peroxidase and superoxide dismutase activity. However, catalase (CAT) activity increased significantly in fish with diets containing 100, 150 and 200 mg PCs per kg of feed. These results suggest a potential protective effect against in vivo lipid peroxidation, and CAT-modulating effects.