Artículo de revista
Autophagy in aging-related oral diseases
Fecha
2022Registro en:
Endocrinol 13:903836 (2022)
10.3389/fendo.2022.903836
Autor
Peña Oyarzún, Daniel
San Martin, Carla
Hernández Cáceres, María Paz
Lavandero González, Sergio Alejandro
Morselli, Eugenia
Budini Budini, Mauricio Fernando
Burgos, Patricia V.
Criollo Céspedes, Alfredo Guillermo
Institución
Resumen
Autophagy is an intracellular degradation mechanism that allows recycling of
organelles and macromolecules. Autophagic function increases metabolite
availability modulating metabolic pathways, differentiation and cell survival.
The oral environment is composed of several structures, including mineralized
and soft tissues, which are formed by complex interactions between epithelial
and mesenchymal cells. With aging, increased prevalence of oral diseases such
as periodontitis, oral cancer and periapical lesions are observed in humans.
These aging-related oral diseases are chronic conditions that alter the
epithelial-mesenchymal homeostasis, disrupting the oral tissue architecture
affecting the quality of life of the patients. Given that autophagy levels are
reduced with age, the purpose of this review is to discuss the link between
autophagy and age-related oral diseases.