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Osteoporosis and autophagy: What is the relationship?
(2017-02-01)
Autophagy is a survival pathway wherein non-functional proteins and organelles are degraded in lysosomes for recycling and energy production. Therefore, autophagy is fundamental for the maintenance of cell viability, acting ...
A new method to measure autophagy flux in the nervous system
(Taylor and Francis Inc., 2014)
A current need in the neuroscience field is a simple method to monitor autophagic activity in vivo in neurons. Until very recently, most reports have been based on correlative and static determinations of the expression ...
Analysis of the role of autophagy inhibition by two complementary human cytomegalovirus BECN1/Beclin 1-binding proteins
(Landes Bioscience, 2015-12)
Autophagy is activated early after human cytomegalovirus (HCMV) infection, but lateron the virus blocks autophagy. Here we characterized 2 HCMV proteins, TRS1 andIRS1, which inhibit autophagy during infection. Expression ...
Autophagy, physiology and cell pathology
(Universidad Nacional de Mar del Plata. Facultad de Medicina. Centro de Investigaciones Cardiovasculares, 2013-12)
Autophagy plays an important role in human pathologies, such as myopathies and neurodegenerative diseases. Moreover, metabolic disease processes such as diabetes and pancreatitis, as well as tumor cells and cancer chemotherapy, ...
Targeting autophagy in neurodegenerative diseases
(Elsevier Ltd, 2014)
© 2014 Elsevier B.V. All rights reserved. The most prevalent neurodegenerative disorders involve protein misfolding and the aggregation of specific proteins. Autophagy is becoming an attractive target to treat neurodegenerative ...
Autophagy: friend or foe in breast cancer development, progression and treatment
(Hindawi Publishing Corporation, 2011-06)
Autophagy is a catabolic process responsible for the degradation and recycling of long-lived proteins and organelles by lysosomes. This degradative pathway sustains cell survival during nutrient deprivation, but in some ...
Targeting autophagy in ALS: A complex mission
(Taylor and Francis Inc., 2011)
Several neurodegenerative diseases share a common neuropathology, primarily featuring the presence of abnormal protein inclusions in the brain containing specific misfolded proteins. Strategies to decrease the load of ...
Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity
(Elsevier, 2016)
Doxorubicin (Doxo) is one of the most effective anti-neoplastic agents but its cardiotoxicity has been an important clinical limitation. The major mechanism of Doxo-induced cardiotoxicity is associated to its oxidative ...
Autophagy: A necessary event during erythropoiesis
(Churchill Livingstone, 2017-09)
Autophagy is a well-known cellular process involved in many physiological and pathological processes. During erythropoiesis, autophagy plays an important role participating in the clearance of unnecessary organelles such ...
Unraveling the role of motoneuron autophagy in ALS
(Taylor and Francis Inc., 2018)
© 2018 Informa UK Limited, trading as Taylor & Francis Group. In recent years, the role of autophagy in the pathogenesis of most neurodegenerative diseases has transitioned into a limbo of protective or detrimental effects. ...