Article
Organophosphorus Pesticides as Modulating Substances of Inflammation through the Cholinergic Pathway
Registro en:
Camacho-Pérez MR, Covantes-Rosales CE, Toledo-Ibarra GA, Mercado-Salgado U, Ponce-Regalado MD, Díaz-Resendiz KJG, Girón-Pérez MI. Organophosphorus Pesticides as Modulating Substances of Inflammation through the Cholinergic Pathway. Int J Mol Sci. 2022 Apr 20;23(9):4523. doi: 10.3390/ijms23094523. PMID: 35562914; PMCID: PMC9104626.
1422-0067 (Electronic)
1422-0067 (Linking)
doi: 10.3390/ijms23094523.
Autor
Camacho Pérez, Milton Rafael
Covantes Rosales, Carlos Eduardo
Toledo Ibarra, Gladys Alejandra
Mercado Salgado, Ulises
Ponce Regalado, María Dolores
Díaz Resendiz, Karina Janice Guadalupe
Girón Pérez, Manuel Iván
Institución
Resumen
Artículo Organophosphorus pesticides (OPs) are widespread insecticides used for pest control in agricultural activities and the control of the vectors of human and animal diseases. However, OPs' neurotoxic mechanism involves cholinergic components, which, beyond being involved in the transmission of neuronal signals, also influence the activity of cytokines and other pro-inflammatory molecules; thus, acute and chronic exposure to OPs may be related to the development of chronic degenerative pathologies and other inflammatory diseases. The present article reviews and discusses the experimental evidence linking inflammatory process with OP-induced cholinergic dysregulation, emphasizing the molecular mechanisms related to the role of cytokines and cellular alterations in humans and other animal models, and possible therapeutic targets to inhibit inflammation.