Organophosphorus Pesticides as Modulating Substances of Inflammation through the Cholinergic Pathway

dc.creatorCamacho Pérez, Milton Rafael
dc.creatorCovantes Rosales, Carlos Eduardo
dc.creatorToledo Ibarra, Gladys Alejandra
dc.creatorMercado Salgado, Ulises
dc.creatorPonce Regalado, María Dolores
dc.creatorDíaz Resendiz, Karina Janice Guadalupe
dc.creatorGirón Pérez, Manuel Iván
dc.date2022-06-22T18:22:59Z
dc.date2022-06-22T18:22:59Z
dc.date2022-04
dc.date.accessioned2023-07-21T21:45:26Z
dc.date.available2023-07-21T21:45:26Z
dc.identifierCamacho-Pérez MR, Covantes-Rosales CE, Toledo-Ibarra GA, Mercado-Salgado U, Ponce-Regalado MD, Díaz-Resendiz KJG, Girón-Pérez MI. Organophosphorus Pesticides as Modulating Substances of Inflammation through the Cholinergic Pathway. Int J Mol Sci. 2022 Apr 20;23(9):4523. doi: 10.3390/ijms23094523. PMID: 35562914; PMCID: PMC9104626.
dc.identifier1422-0067 (Electronic)
dc.identifier1422-0067 (Linking)
dc.identifierdoi: 10.3390/ijms23094523.
dc.identifierhttp://repositorio.cualtos.udg.mx:8080/jspui/handle/123456789/1353
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/7752827
dc.descriptionArtículo
dc.descriptionOrganophosphorus pesticides (OPs) are widespread insecticides used for pest control in agricultural activities and the control of the vectors of human and animal diseases. However, OPs' neurotoxic mechanism involves cholinergic components, which, beyond being involved in the transmission of neuronal signals, also influence the activity of cytokines and other pro-inflammatory molecules; thus, acute and chronic exposure to OPs may be related to the development of chronic degenerative pathologies and other inflammatory diseases. The present article reviews and discusses the experimental evidence linking inflammatory process with OP-induced cholinergic dysregulation, emphasizing the molecular mechanisms related to the role of cytokines and cellular alterations in humans and other animal models, and possible therapeutic targets to inhibit inflammation.
dc.languageen
dc.publisherMDPI
dc.relationInternational journal of molecular sciences.;2022 Apr 20;23(9):4523
dc.subjectcholinergic system
dc.subjectinflammation
dc.subjectorganophosphorus pesticides
dc.titleOrganophosphorus Pesticides as Modulating Substances of Inflammation through the Cholinergic Pathway
dc.typeArticle


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