Study of nanosponges base don carbonate as nanoencapsulation system of lipophilic compound

Abstract

Piperine (PIP) is an alkaloid extracted from the seeds of black pepper, which despite its beneficial properties, its application in foods is still limited due to the low solubility in water, low bioavailability and high pungency¹. The nanosponges (NS) based on cyclodextrin are hyper reticulated polymer structures with nanometer cavities. Which can selectively capture, transport and release a wide variety of substances and mask the unpleasant taste². STUDY OF NANOSPONGE BASED ON CYCLODEXTRIN AND CARBONATE AS A NANOENCAPSULATION SYSTEM OF LIPOPHILIC COMPOUND Gonzalez, S2., Guineo, J.P1.,Hermosilla, J., Rubilar, M2. 1Master of Engineering Sciences with Specialization in Biotechnology, Universidad de La Frontera, Temuco, Chile. 2Department of Chemical Engineering, Faculty of Engineering and Science, Scientific and Technological Bioresource Nucleus, BIOREN, Universidad de La Frontera, Temuco, Chile. 2. Methods The NS were formed with β-cyclodextrin:diphenyl carbonate (β-CD:DC) molar ratio of 1:2, 1:6 and 1:10 by solvent method at 90°C for 5 hours3. The NS 1:6 and 1:10 was loaded in PIP:NS ratio of 1:2 in different encapsulation media (ethanol and acetone) (Fig. 1). 3. Results The NS formation (Fig. 2) and the PIP inclusion (Table 1 and Fig 3) were confirmed by FTIR. These NS (Fig. 6) reached DS of 2,6 (1:6) and 3,4 (1:10) with PIP loading efficiency in the ethanol dispersion medium of 69.9 ± 1.55% (1: 6) and 89.9% (1:10) and 46,7± 1.56% (1: 6) and 53,1± 0,93% (1:10) in the dispersion medium acetone. However, they showed a hydrolyzation in their structure that affected the PIP loading capacity. Objective: To evaluate nanosponges based on cyclodextrin and carbonate as piperine (PIP) nanoencampsulation system.