| dc.description.abstract | Piperine (PIP) is an alkaloid extracted from the seeds of black
pepper, which despite its beneficial properties, its application
in foods is still limited due to the low solubility in water, low
bioavailability and high pungency¹. The nanosponges (NS)
based on cyclodextrin are hyper reticulated polymer structures
with nanometer cavities. Which can selectively capture,
transport and release a wide variety of substances and mask
the unpleasant taste².
STUDY OF NANOSPONGE BASED ON CYCLODEXTRIN
AND CARBONATE AS A NANOENCAPSULATION
SYSTEM OF LIPOPHILIC COMPOUND
Gonzalez, S2., Guineo, J.P1.,Hermosilla, J., Rubilar, M2.
1Master of Engineering Sciences with Specialization in Biotechnology, Universidad de La Frontera, Temuco, Chile.
2Department of Chemical Engineering, Faculty of Engineering and Science, Scientific and Technological
Bioresource Nucleus, BIOREN, Universidad de La Frontera, Temuco, Chile.
2. Methods
The NS were formed with
β-cyclodextrin:diphenyl
carbonate (β-CD:DC)
molar ratio of 1:2, 1:6 and
1:10 by solvent method at
90°C for 5 hours3. The NS
1:6 and 1:10 was loaded in
PIP:NS ratio of 1:2 in
different encapsulation
media (ethanol and
acetone) (Fig. 1).
3. Results
The NS formation (Fig. 2) and the PIP inclusion (Table 1
and Fig 3) were confirmed by FTIR. These NS (Fig. 6)
reached DS of 2,6 (1:6) and 3,4 (1:10) with PIP loading
efficiency in the ethanol dispersion medium of 69.9 ±
1.55% (1: 6) and 89.9% (1:10) and 46,7± 1.56% (1: 6) and
53,1± 0,93% (1:10) in the dispersion medium acetone.
However, they showed a hydrolyzation in their structure
that affected the PIP loading capacity.
Objective: To evaluate nanosponges based on cyclodextrin
and carbonate as piperine (PIP) nanoencampsulation
system. | |
