Ligand-mediated galectin-1 endocytosis prevents intraneural h2o2 production promoting f-actin dynamics reactivation and axonal re-growth

Abstract

Axonal growth cone collapse following spinal cord injury (SCI) is promoted by semaphorin3A (Sema3A) signaling via PlexinA4 surface receptor. This interaction triggers intracellular signaling events leading to increased hydrogen peroxide levels which in t