info:eu-repo/semantics/article
Autophagy and proteins involved in vesicular trafficking
Fecha
2015-11Registro en:
Amaya, Celina; Fader Kaiser, Claudio Marcelo; Colombo, Maria Isabel; Autophagy and proteins involved in vesicular trafficking; Elsevier Science; FEBS Letters; 589; 22; 11-2015; 3343-3353
0014-5793
CONICET Digital
CONICET
Autor
Amaya, Celina
Fader Kaiser, Claudio Marcelo
Colombo, Maria Isabel
Resumen
Autophagy is an intracellular degradation system that, as a basic mechanism it delivers cytoplasmic components to the lysosomes in order to maintain adequate energy levels and cellular homeostasis. This complex cellular process is activated by low cellular nutrient levels and other stress situations such as low ATP levels, the accumulation of damaged proteins or organelles, or pathogen invasion. Autophagy as a multistep process involves vesicular transport events leading to tethering and fusion of autophagic vesicles with several intracellular compartments. This review summarizes our current understanding of the autophagic pathway with emphasis in the trafficking machinery (i.e. Rabs GTPases and SNAP receptors (SNAREs)) involved in specific steps of the pathway.