Resenha
Advances in prodrug design
Fecha
2005-10-01Registro en:
Mini-Reviews in Medicinal Chemistry, v. 5, n. 10, p. 893-914, 2005.
1389-5575
10.2174/138955705774329528
WOS:000231837000003
2-s2.0-24944549193
9734333607975413
0000-0003-4141-0455
Autor
Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
Resumen
The background of prodrug design is presented herein as the basis for introducing new and advanced latent systems, taking into account mainly the versatility of polymers and other macromolecules as carriers. PDEPT (Polymer-Directed Enzyme Prodrug Therapy); PELT (Polymer-Enzyme Liposome Therapy); CDS (Chemical Delivery System); ADEPT(Antibody-Directed Enzyme Prodrug Therapy); GDEPT/VDEPT (Gene-Directed Enzyme Prodrug Therapy/Virus-Directed Enzyme Prodrug Therapy); ODDS (Osteotropic Drug Delivery System) and LEAPT (Lectin-directed enzyme-activated prodrug therapy) are briefly described and some examples are given. © 2005 Bentham Science Publishers Ltd.
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