Potential tuberculostatic agents: Micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid

Artigo

Fecha

2001-06-01

Registro en:

Archiv Der Pharmazie. Berlin: Wiley-v C H Verlag Gmbh, v. 334, n. 6, p. 189-193, 2001.

0365-6233

http://hdl.handle.net/11449/7577

10.1002/1521-4184(200106)334:6<189

WOS:000169717500002

http://repositorioslatinoamericanos.uchile.cl/handle/2250/3884417

Autor

Universidade Estadual Paulista (Unesp)

Universidade de São Paulo (USP)

Institución

Universidade Paulista Júlio de Mesquita Filho (Brasil)

Resumen

With the objective of obtaining slow-acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle-forming copolymer of poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium Il(tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug.

Materias

potential tuberculostatic agent

isoniazid

prodrug

micelle-forming polymer

co-polymer poly(ethylene glycol)-poly(aspartic acid)

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