Artigo
Potential tuberculostatic agent: Micelle-forming pyrazinamide prodrug
Fecha
2006-06-01Registro en:
Archiv Der Pharmazie. Weinheim: Wiley-v C H Verlag Gmbh, v. 339, n. 6, p. 283-290, 2006.
0365-6233
10.1002/ardp.200500039
WOS:000238395100001
Autor
Universidade Estadual Paulista (Unesp)
Universidade de São Paulo (USP)
Universidade Federal de São Carlos (UFSCar)
Instituto Adolfo Lutz (IAL)
Resumen
Pyrazinamide was condensed with the poly(ethylene glycol)-poly(aspartic acid) copolymer (PEG-PASP), a micelle-forming derivative was obtained that was characterized in terms of its critical micelle concentration (CMC) and micelle diameter. The CMC was found by observing the solubility of Sudan III in Poly(ethylene glycol)-poly(pyrazinamidomethyl aspartate) copolymer (PEG-PASP-PZA) solutions. The mean diameter of PEG-PASP-PZA micelles, obtained by analyzing the dynamic light-scattering data, was 78.2 nm. The PEG-PASP-PZA derivative, when assayed for anti-Mycobacterium activity, exhibited stronger activity than the simple drug.