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Mostrando ítems 11-20 de 1209
Alternative splicing variant of RHBDD2 is associated with cell stress response and breast cancer progression
(Spandidos Publications, 2018-08)
RHBDD2 is an intramembrane pseudoprotease member of the Rhomboid superfamily. Our previous studies in breast and colorectal cancer indicate an association between RHBDD2 overexpression and advanced tumor stages. Two ...
GJB2 and GJB6 genetic variant curation in an Argentinean non-syndromic hearing-impaired cohort
(MDPI AG, 2020-10-21)
Genetic variants in GJB2 and GJB6 genes are the most frequent causes of hereditary hearing loss among several deaf populations worldwide. Molecular diagnosis enables proper genetic counseling and medical prognosis to ...
Herpes simplex virus type 1 variants arising after selection with an antiviral carrageenan: Lack of correlation between drug susceptibility and syn phenotype
(Wiley-liss, Div John Wiley & Sons Inc, 2002-09)
Natural carrageenans of diverse structural types isolated from the red seaweed Gigartina skottsbergii have been recently identified as potent and selective inhibitors of herpes simplex virus (HSV) types 1 and 2. The m/n ...
A novel recombinant variant of latent membrane protein 1 from Epstein Barr virus in Argentina denotes phylogeographical association
(Public Library of Science, 2017-03)
Epstein Barr virus (EBV) infection in Argentina occurs at an early age and occasionally develops infectious mononucleosis (IM). EBV is also related with lymphomas. LMP1, the viral oncoprotein is polymorphic and is used to ...
Curating the gnomAD database: Report of novel variants in the globin‐coding genes and bioinformatics analysis
(Wiley-liss, Div John Wiley & Sons Inc, 2019-09-25)
Massive parallel sequencing technologies are facilitating the faster identification of sequence variants with the consequent capability of untangling the molecular bases of many human genetic syndromes. However, it is not ...
El mito de Alcestis: variantes e interpretaciones desde Homero a la antigüedad tardíaThe Alcestis myth: variants and interpretations from Homer to late antiquity
(Universidade de Brasília, 2016-05)
El propósito de este artículo es comentar de manera sumaria el recorrido del mito de Alcestis a lo largo de la literatura clásica, sobre todo para encontrar variantes significativas de los mitemas, puesto que en esas ...
Descripción de un Caso de Leucemia Mieloide Crónica con un Cromosoma Philadelphia VarianteA case of chronic myeloid leukemia with Philadelphia chromosome variant
(Universidad Nacional de Misiones. Facultad de Ciencias Exactas - Químicas y Naturales. Centro de Investigación y Desarrollo Tecnológico, 2017-03)
En 5-10% de los casos de Leucemia Mieloide Crónica (LMC), el cromosoma Philadelphia (Ph1) se origina como producto de translocaciones variantes (Ph1 variante). Estas últimas involucran otros autosomas además del 9 y 22 ...
Structure and genetic variants of thyroglobulin: Pathophysiological implications
(Elsevier Ireland, 2021-05)
Thyroglobulin (TG) plays a main role in the biosynthesis of thyroid hormones (TH), and, thus, it is involved in a wide range of vital functions throughout the life cycle of all vertebrates. Deficiency of TH production due ...
Evolution of Canine Parvovirus in Argentina between years 2003 and 2010: CPV2c has become the predominant variant affecting the domestic dog population
(Elsevier Science, 2011-04)
The current frequency of Canine Parvovirus variants (CPV2a, CPV2b and CPV2c) in the Argentine dog population was investigated by PCR amplification of a 583. bp fragment in the VP2 gene. From a total of 79 rectal swab samples ...
Characterization of the molecular changes associated with the overexpression of a novel epithelial cadherin splice variant mRNA in a breast cancer model using proteomics and bioinformatics approaches: identification of changes in cell metabolism and an in
(Springer, 2019-05)
Breast cancer (BC) is the most common female cancer and the leading cause of cancer death in women worldwide. Alterations in epithelial cadherin (E-cadherin) expression and functions are associated to BC, but the underlying ...