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Precision Medicine in the Renin Angiotensin System Therapeutic Targets and Biological Variability
(Bentham Science Publishers, 2020-07)
Abstract: Pathologies linked to the renin angiotensin system are frequent, and the drugs used in them are numerous and show great variability in therapeutic effects and adverse reactions. Genetic variants have been detected ...
Chemoprophylactic and therapeutic efficacy of thymol in murine cystic echinococcosis
(Elsevier Ireland, 2015-10)
Cystic echinococcosis is a zoonotic disease caused by the larval stage of the cestode Echinococcus granulosus. The drugs commonly used against cystic echinococcosis are benzimidazoles. Unfortunately, 20%-40% of cases do ...
Therapeutic targets to reduce the contribution of pulmonary neutrophilic inflammation towards obesity-associated co-morbidities: a mini-review
(Medwin Publishers, 2019-08)
Epidemiology and experimental models have shown a close link between adipose tissue inflammation, systemic inflammation and pulmonary neutrophilic inflammation, which predispose obese patients to pulmonary diseases, ...
Pharmacological approaches towards rationalizing the use of endoparasitic drugs in small animals
(Wiley Blackwell Publishing, Inc, 2006-12)
Parasitic diseases are an important health concern to small animal veterinarians worldwide, and their zoonotic potential is also of relevance to human medicine. The treatment and control of such conditions relies heavily ...
The transferrin receptor and the targeted delivery of therapeutic agents against cancer
(Elsevier Science, 2012-03)
Background: Traditional cancer therapy can be successful in destroying tumors, but can also cause dangerous side effects. Therefore, many targeted therapies are in development. The transferrin receptor (TfR) functions in ...
Cruzipain and Its Physiological Inhibitor, Chagasin, as a DNA-Based Therapeutic Vaccine Against Trypanosoma cruzi
(Frontiers Media S.A., 2020-10)
Chagas disease caused by the protozoan parasite Trypanosoma cruzi is endemic in 21 Latin American countries and the southern United States and now is spreading into several other countries due to migration. Despite the ...
Potential use of vanadium compounds on therapeutics
(Bentham Science Publishers, 2010-11)
Vanadium is a trace element present in practically all cells in plants and animals. While the essentiality of vanadium for human beings remains to be well established, vanadium has become an increasingly important environmental ...
Immunity and vaccine development efforts against Trypanosoma cruzi
(Elsevier Science, 2019-12)
Trypanosoma cruzi (T. cruzi) is the causative agent for Chagas disease (CD). There is a critical lack of methods for prevention of infection or treatment of acute infection and chronic disease. Studies in experimental ...
Therapeutic utility of glucocorticoids and antihistamines cotreatment. Rationale and perspectives
(Wiley, 2019-12)
Antihistamines and glucocorticoids (GCs) are often used together in the clinic, in several inflammatory-related situations. Even though there is no clear rationale for this drug association, the clinical practice is based ...
Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics
(Informa Healthcare, 2019-12)
Drug repurposing(or repositioning) implies finding new therapeutic indications for existingdrugs (including approved, failed, discontinued and experimental drugs), andrepresents a substantial percentage of recent drug ...