info:eu-repo/semantics/article
Chemoprophylactic and therapeutic efficacy of thymol in murine cystic echinococcosis
Date
2015-10Registration in:
Maggiore, Marina Alejandra; Pensel, Patricia Eugenia; Denegri, Guillermo Maria; Elissondo, María Celina; Chemoprophylactic and therapeutic efficacy of thymol in murine cystic echinococcosis; Elsevier Ireland; Parasitology International; 64; 5; 10-2015; 435-440
1383-5769
CONICET Digital
CONICET
Author
Maggiore, Marina Alejandra
Pensel, Patricia Eugenia
Denegri, Guillermo Maria
Elissondo, María Celina
Abstract
Cystic echinococcosis is a zoonotic disease caused by the larval stage of the cestode Echinococcus granulosus. The drugs commonly used against cystic echinococcosis are benzimidazoles. Unfortunately, 20%-40% of cases do not respond favorably to such chemotherapy. Consequently, the search of new therapeutic alternatives such as the use of traditional medicinal plants has been increased. The aim of the current experimental work was to investigate the chemoprophylactic and clinical efficacy of thymol on mice infected with E. granulosus metacestodes. Thymol (40. mg/kg) was administered under two different therapeutic schemes: dosing every 24. h over 20. days and treatment every 12. h for 10. days. Thymol demonstrated efficacy against experimental murine cystic echinococcosis. The chemoprophylactic and therapeutic effects of thymol were comparable to that of albendazole. Due to the lack of toxicity observed in mice at the tested doses; we consider that thymol is a potential alternative to be applied for the treatment of human hydatid disease.