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Leptin protects placental cells from apoptosis induced by acidic stress
(Springer, 2019-03)
Development of the human placenta is critical for a successful pregnancy. The placenta allows the exchange of oxygen and carbon dioxide and is crucial to manage acid-base balance within a narrow pH. It is known that low ...
Role of leptin in female reproduction
(De Gruyter, 2015-01)
Reproductive function is dependent on energy resources. The role of weight, body composition, fat distribution and the effect of diet have been largely investigated in experimental female animals as well as in women. Any ...
Complex relationship between sex hormones, insulin resistance and leptin in men with and without prostatic disease
(Informa Healthcare, 2016-01)
Objectives: To assess sex hormones, leptin and insulin-resistance in men with prostate cancer (PCa) and benign prostatic hyperplasia (BPH) and to study associations between androgens and histologic score of prostate tissue ...
Leptin increases prostate cancer aggressiveness
(Springer, 2011-05)
Recent studies indicate that adipose tissue and adipocytokines might affect the development of prostate cancer (PCa). Leptin would have a stimulating effect on prostate cancer cells by inducing promotion and progression, ...
Functional implications of limited leptin receptor and ghrelin receptor coexpression in the brain
(Wiley-liss, Div John Wiley & Sons Inc, 2012-02)
The hormones leptin and ghrelin act in apposition to one another in the regulation of body weight homeostasis. Interestingly, both leptin receptor expression and ghrelin receptor expression have been observed within many ...
Differential effects of leptin on ovarian metalloproteinases and their tissue inhibitors between in vivo and in vitro studies
(BioScientifica, 2011-04)
In this study, we investigated the effect of leptin on the ovarian metalloproteinase system in the rat during the ovulatory process. Ovulation was induced in immature rats primed with gonadotropins. In both in vitro and ...
Oral Leptin Treatment in Suckling Rats Ameliorates Detrimental Effects in Hypothalamic Structure and Function Caused by Maternal Caloric Restriction during Gestation
(Public Library of Science, 2013-11)
A poor prenatal environment brings about perturbations in leptin surge and hypothalamic circuitry that program impaired ability to regulate energy homeostasis in adulthood. Here, using a rat model of moderate maternal ...
Sam68 mediates leptin-stimulated growth by modulating leptin receptor signaling in human trophoblastic JEG-3 cells
(Oxford University Press, 2011)
Association between diencephalic thyroliberin and arterial blood pressure in agouti-yellow and ob/ob mice may be mediated by leptin
(W B Saunders Co-Elsevier Inc, 2007-10)
Leptin, a hormone secreted by the adipose tissue, stimulates anorexigenic peptides and also inhibits orexigenic peptides in hypothalamic arcuate nuclei-located neurons. It also counteracts the starvation-induced suppression ...
Leptin upregulates aquaporin 9 expression in human placenta in vitro
(Informa Healthcare, 2018-02)
Aquaporins are integral membrane proteins that have permeability functions in many tissues. Aquaporin 9 may transport not only water but also small molecules, such as glycerol, monocarboxylates, purines and pyrimidines. ...