info:eu-repo/semantics/article
Leptin increases prostate cancer aggressiveness
Fecha
2011-05Registro en:
López Fontana, Constanza Matilde; Maselli, María Eugenia; Pérez Elizalde, Rafael F.; Di Milta Mónaco, Nicolás A.; Uvilla Recupero, Ana L.; et al.; Leptin increases prostate cancer aggressiveness; Springer; Journal of physiology and biochemistry; 67; 4; 5-2011; 531-538
1138-7548
1877-8755
CONICET Digital
CONICET
Autor
López Fontana, Constanza Matilde
Maselli, María Eugenia
Pérez Elizalde, Rafael F.
Di Milta Mónaco, Nicolás A.
Uvilla Recupero, Ana L.
López Laur, José D.
Resumen
Recent studies indicate that adipose tissue and adipocytokines might affect the development of prostate cancer (PCa). Leptin would have a stimulating effect on prostate cancer cells by inducing promotion and progression, whereas adiponectin would have a protective effect. The aim of this study was to determine the relation between body composition, leptin, and adiponectin levels with the prevalence and aggressiveness of PCa in men of Mendoza, Argentina. Seventy volunteers between 50 and 80 years (35 healthy men as control group and 35 with PCa) were selected. The PCa group was subclassified according to the Gleason Score (GS). Digital rectal examination, transrectal ultrasound, and prostatic biopsy were performed; PSA, testosterone, leptin, and adiponectin levels were determined; and a nutritional interview including anthropometric measurements and a food frequency questionnaire was carried out. Statistical analysis was performed by Student t test, ANOVA I, and Bonferroni (p < 0.05). Body mass index and percentage of body fat mass were not statistically different between PCa and control groups. However, body fat mass was higher in subjects with more aggressive tumors (p = 0.032). No differences were observed regarding leptin levels between the groups. Nevertheless, leptin levels were higher in subjects with high GS (p < 0.001). Adiponectin levels showed no statistical differences regarding the presence and aggressiveness of the tumor (p = 0.131). Finally, consumption and nutrient intake did not differ in the studied groups. In conclusion, body composition and leptin are related to the PCa aggressiveness but not with its prevalence.