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Preface for buccal drug delivery theme issue
(Informa Healthcare, 2014)
During the past years, buccal drug delivery has attracted the attention of researchers looking for alternative delivery routes of administration. As an alternative to oral drug delivery, the buccal mucosal route avoids the ...
Delivery of ionizable hydrophilic drugs based on pharmaceutical formulation of ion pairs and ionic liquids
(Elsevier, 2020)
New therapeutics such as antisense oligonucleotides, small interfering RNA and peptide-drug conjugates are taking great relevance in the pharmaceutical industry due to their specificity of action and their improved safety ...
Preparation of a novel lipid-core micelle using a low-energy emulsification method
(Springer Verlag, 2018)
High-energy methods for the manufacturing of nanomedicines are widely used; however, interest in low-energy methods is increasing due to their simplicity, better control over the process, and energy-saving characteristics ...
El sistema internacional de fiscalización de drogas : un estado de cosas para cambiar.
(Universidad Catolica de Colombia, 2009-07-01)
El modelo de la política de “guerra contra las drogas” plantea el dilema de establecer si los daños asociados con sus estrategias represivas contribuyen a reducir el daño causado por las drogas o si, por el contrario, se ...
Dissolution kinetics evaluation of controlled-release tablets containing propranolol hydrochloride
(Marcel Dekker Inc., 1999)
In the present research, controlled-release propranolol hydrochloride tablets were prepared for twice-daily administration, allowing more uniform plasmatic levels of the drug. Pharmaceutical formulations were prepared with ...
Isobolographic analysis of the antinociceptive interactions of clonidine with nonsteroidal anti-inflammatory drugs
(ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 2004-09)
The present study was undertaken to characterize the interactions between nonsteroidal anti-inflammatory drugs and the alpha(2)-adrenoceptor agonist clonidine in an acute nociceptive test. The writhing test was selected ...
New challenges and promises in solid organ transplantation pharmacogenetics: the genetic variability of proteins involved in the pharmacodynamics of immunosuppressive drugs
(Future Medicine, 2016)
Interindividual variability in immunosuppressive drug responses might be partly explained by
genetic variants in proteins involved in the immune response or associated with IS
pharmacodynamics. On a general basis, the ...
Local anesthetic effect of some benzoate compounds and diethylaminoethanol and their influence on procaine activity
(1973)
Sodium benzoate, ammonium benzoate, sodium p amino benzoate (PAB) and diethylaminoethanol (DEAE) alone and in conjunction with procaine have been tested as blocking conduction agents on frog desheathed sciatic nerves and ...
Medicinal chemistry targeting mitochondria: From new vehicles and pharmacophore groups to old drugs with mitochondrial activity
(MDPI, 2020)
Interest in tumor cell mitochondria as a pharmacological target has been rekindled in recent years. This attention is due in part to new publications documenting heterogenous characteristics of solid tumors, including ...
Aminochrome as New Preclinical Model to Find New Pharmacological Treatment that Stop the Development of Parkinson's Disease
(Bentham Science, 2016)
The pharmacological treatment of Parkinson's disease (PD) is limited to dopamine agonists and anti-cholinergic drugs that do not stop the progress of disease. L-Dopa was introduced to the treatment in 1967; this drug is ...