Artículo de revista
Dissolution kinetics evaluation of controlled-release tablets containing propranolol hydrochloride
Fecha
1999Registro en:
Drug Development and Industrial Pharmacy, Volumen 25, Issue 4, 2018, Pages 535-541
03639045
10.1081/DDC-100102205
Autor
Velasco-De-Paola, M. V.R.
Santoro, M. I.R.M.
Gai, M. N.
Institución
Resumen
In the present research, controlled-release propranolol hydrochloride tablets were prepared for twice-daily administration, allowing more uniform plasmatic levels of the drug. Pharmaceutical formulations were prepared with hydrophobic Eudragit® RSPO. The physical properties of the tablets were determined. Dissolution tests were performed in capsules containing the raw material using the following dissolution media: (A) distilled water, (B) simulated gastric juice without enzymes, and (C) simulated enteric juice without enzymes. A dissolution test was also performed for simulated samples (tablets) using distilled water as the dissolution medium.