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Resistance acquired to third generation tyrosine kinase inhibitors in non small cell lung cancerResistencia adquirida a inhibidores de tirosina kinasa de tercera generación en cáncer de pulmón de células no pequeñas
(Universidad Nacional Mayor de San Marcos, Facultad de Medicina Humana, 2018)
Effect of hyperthyroidism on circulating prolactin and hypothalamic expression of tyrosine hydroxylase, prolactin signaling cascade members and estrogen and progesterone receptors during late pregnancy and lactation in the rat
(Elsevier Ireland, 2017-02)
Hyperthyroidism (HyperT) compromises pregnancy and lactation, hindering suckling-induced PRL release. We studied the effect of HyperT on hypothalamic mRNA (RT-qPCR) and protein (Western blot) expression of tyrosine hydroxylase ...
Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis
(Public Library of Science, 2021-01)
Tsetse transmit African trypanosomiasis, which is a disease fatal to both humans and animals. A vaccine to protect against this disease does not exist so transmission control relies on eliminating tsetse populations. ...
Tyrosine phosphorylation differentially fine-tunes ionotropic and metabotropic responses of human α7 nicotinic acetylcholine receptor
(Springer Nature Switzerland, 2021-05-24)
The α7 nicotinic acetylcholine receptor is involved in neurological, neurodegenerative, and inflammatory disorders. It operates both as a ligand-gated cationic channel and as a metabotropic receptor in neuronal and ...
New mutation L324M in the ABL1 kinase domain: does it confer high resistance to second-generation inhibitors?
(Taylor & Francis Ltd, 2014-03)
In chronic myeloid leukemia (CML) the presence of mutations in the tyrosine kinase domain (TK) of the normalABL1 gene is the most common cause of loss of response to treatment. Detection of these mutations is an important ...
Subcellular distribution of ERK phosphorylation in tyrosine and threonine depends on redox status in murine lung cells
(Public Library of Science, 2018-02)
Activation of ERK1/2 implies the phosphorylation of tyrosine (pTyr) and threonine (pThr) by MEK1/2; both reactions were thought to be cytoplasmic, promoting ERK to reach the nucleus where it activates several transcription ...
Tyrosine phosphatases in steroidogenic cells: Regulation and function
(Elsevier Ireland, 2007-02)
In adrenocortical and Leydig cells PKA activation by trophic hormones increases the activity of protein tyrosine phosphatases and also induces the expression of MAP kinase phosphatase 1 (MKP-1), a dual activity protein ...