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Evidence of absence of Trypanosoma cruzi kinetoplast DNA methylation by restriction endonuclease analysis
(1991)
Evidence of absence of Trypanosoma cruzi kinetoplast DNA methylation by restriction endonuclease analysis. International Journal for Parasitology bd21: 863-866. Eight kinetoplast DNA samples from very different T. cruzi ...
DNA methylation in Trypanosoma cruzi
(1990)
DNA isolated from the protozoan Trypanosoma cruzi has been found to contain 5-methylcytosine. Analysis of T. cruzi DNA by both HpaII and MspI restriction endonucleases suggests that the sequence -CCGG- is not methylated. ...
Nonsyndromic orofacial clefts in Chile: LINE-1 methylation and MTHFR variants
(Future Medicine, 2020)
Aim: To evaluate the risk of nonsyndromic orofacial clefts (NSOFCs) associated with LINE-1 methylation, as a marker of global DNA methylation, and the effect of MTHFR functional variants on this variable. Patients & methods: ...
High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans
(BIOMED Central Ltd., 2017)
Background: Changes in DNA methylation, one of the most studied epigenetic mechanisms, are considered an initial marker for early cancer detection. We evaluated how availability of dietary factors (folates and vitamin B12) ...
Global DNA methylation and homocysteine levels are lower in type 1 diabetes patients La metilación global del ADN y los niveles de homocisteína en plasma se encuentran disminuidos en pacientes con diabetes mellitus tipo 1
(Sociedad Medica de Santiago, 2015)
© 2015 Sociedad Medica de Santiago. All Rights Reserved. Background: The worldwide rise in the incidence of Type 1 Diabetes (T1D), and the concordance rate between monozygotic twins (50%), indicate a strong effect of the ...
Genomic imprinting and embryonic development Impronta genómica y desarrollo embrionario
(2012)
SUMMARY: In diploid organisms, autosomal genes are composed of two copies, or alleles, inherited from both parents at fertilization. For the vast majority of autosomal genes, expression occurs from both alleles simultaneously. ...
La metilación global del ADN y los niveles de homocisteína en plasma se encuentran disminuidos en pacientes con diabetes mellitus tipo 1
(Sociedad Médica de Santiago, 2015)
Background: The worldwide rise in the incidence of Type I Diabetes (T1D), and the concordance rate between monozygotic twins (50%), indicate a strong effect of the environment as an underlying factor of this disease. This ...
Folic Acid Supplementation during Pregnancy Induces Sex-Specific Changes in Methylation and Expression of Placental 11 beta-Hydroxysteroid Dehydrogenase 2 in Rats
(Public Library Science, 2015)
In the placenta, 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) limits fetal glucocorticoid exposure and its inhibition has been associated to low birth weight. Its expression, encoded by the HSD11B2 gene is ...
GADD45α modulates DNA methylation induced by DNA damage during homologous recombination
(Biomédica, Mecatrónica y MecánicaEscuela de Ingeniería de Antioquia EIAUniversidad CES, 2014-04-23)
Homologous recombination is one of the major pathways for repairing DNA double strand breaks, the most
deleterious of DNA lesions. Recent studies suggest that DNA methylation events target homologous recombination ...