Artículo de revista
DNA methylation in Trypanosoma cruzi
Fecha
1990Registro en:
FEBS Letters, Volumen 263, Issue 1, 1990, Pages 113-116
00145793
10.1016/0014-5793(90)80717-W
Autor
Rojas, M.Véronica
Galanti Garrone, Norbel
Institución
Resumen
DNA isolated from the protozoan Trypanosoma cruzi has been found to contain 5-methylcytosine. Analysis of T. cruzi DNA by both HpaII and MspI restriction endonucleases suggests that the sequence -CCGG- is not methylated. Probably T. cruzi DNA also contains N6-methyladenine. This report constitutes the first clear demonstration of the presence of methylated bases in the nuclear DNA from trypanosomes.