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La teoría de sistemas en desarrollo : una vía para resolver la tensión entre las perspectivas “internalista” y “externalista” en la biología evolutivaDevelopmental systems theory : a way to solve the tension between “internalist”and “externalist” perspectives in evolutionary biology
(Universidad Nacional de QuilmesUniversidad Nacional de Tres de Febrero, 2017-10-01)
La teoría de sistemas en desarrollo (TSD) define una vía para solucionar el debate “externalismo/internalismo” en las teorías de la evolución abriendo el camino hacia una síntesis expandida. Para justificar que la epigénesis ...
Editorial: Emergent Effects of Noise in Biology: From Gene Expression to Cell Motility
(Frontiers Media S.A., 2019-05)
Deterministic modeling coarse-grains unitary events into population behavior, however this approach often misses the diversity of responses in cellular and molecular systems, due to long-time effects of stochastic fluctuations. ...
Genetic pathways in nonalcoholic fatty liver disease: Insights from systems biology
(John Wiley & Sons Inc, 2020-03-14)
Nonalcoholic fatty liver disease (NAFLD) represents a burgeoning worldwide epidemic whose etiology reflects multiple interactions between environmental and genetic factors. Here we review the major pathways and dominant ...
Fetal metabolic programming and epigenetic modifications: a systems biology approach
(Nature Publishing Group, 2013-04)
A growing body of evidence supports the notion that epigenetic changes such as DNA methylation and histone modifications, both involving chromatin remodeling, contribute to fetal metabolic programming. We use a combination ...
Functional scale-free networks in the two-dimensional Abelian sandpile model
(American Physical Society, 2015-07)
Recently, the similarity of the functional network of the brain and the Ising model was investigated by Chialvo [Nat. Phys. 6, 744 (2010)]. This similarity supports the idea that the brain is a self-organized critical ...
Lazer–Leach conditions for coupled Gompertz-like delayed systems
(Pergamon-Elsevier Science Ltd, 2018-09)
A coupled Gompertz-like system of delay differential equations is considered. We prove the existence of T-periodic solutions under resonance assuming a Lazer–Leach type condition.
La bioinformática y la biología de sistemas
(Secretaría de Posgrado. Universidad Nacional de Quilmes, 2017-05-31)
Review article: Shared disease mechanisms between non-alcoholic fatty liver disease and metabolic syndrome – translating knowledge from systems biology to the bedside
(Wiley Blackwell Publishing, Inc, 2019-03)
Background/Aim: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease worldwide. Characterised by abnormal fat accumulation in the liver, NAFLD presents high degree of comorbidity with ...
Ultrasensitivity in signaling cascades revisited: Linking local and global ultrasensitivity estimations
(Public Library of Science, 2017-06)
Ultrasensitive response motifs, capable of converting graded stimuli into binary responses, are well-conserved in signal transduction networks. Although it has been shown that a cascade arrangement of multiple ultrasensitive ...
Electron capture by swift ions from molecules of biological interest
(IOP Publishing, 2018-07)
Electron capture from molecular targets impacted by swift ions, H+, He2+, Li3+ and C6+, is investigated in the framework of the quantum-mechanical continuum distorted wave-Eikonal initial state model. Biological molecules ...