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Structural features and antiviral activity of sulphated fucans from the brown seaweed Cystoseira indica
(International Medical Press, 2007-06)
Natural compounds offer interesting pharmacological perspectives for antiviral drug development. In this study, we have analysed sulphated-fucan-containing fractions isolated from the brown seaweed Cystoseira indica. The ...
Antiviral and Virucidal Activities against Arenaviruses of Zinc-Finger Active Compounds
(International Medical Press, 2016-06)
Fifteen antiretroviral Zn-finger active compounds with diverse chemical structures, including azoic compounds, hydrazide derivatives, disulfide-based reagents and others, were screened in vitro against Junin virus (JUNV), ...
Inhibition of Junin virus RNA synthesis by an antiviral acridone derivative
(Elsevier Science, 2012-01)
There are no specific approved drugs for the treatment of agents of viral hemorrhagic fevers (HF) and antiviral therapies against these viruses are urgently needed. The present study characterizes the potent and selective ...
Sulfated xylomannans from the red seaweed Sebdenia polydactyla: Structural features, chemical modification and antiviral activity
(International Medical Press, 2009-04)
Background: Many viruses display affinity for cell surface heparan sulfate proteoglycans with biological relevance in virus entry. This raises the possibility of the application of sulfated polysaccharides in antiviral ...
Modified ribavirin analogues as antiviral agents against Junín virus
(Elsevier, 2019-02)
In this work, several ribavirin analogues were synthesized and incorporated into a multivalent arrangement. Both were subsequently modified by the addition of polyhydroxylated residues. Their antiviral activity was tested ...
Structural analysis and antiviral activity of a sulfated galactan from the red seaweed Schizymenia binderi (Gigartinales, Rhodophyta)
(Elsevier, 2005-10)
Aqueous extraction of gametophytic Schizymenia binderi afforded a polysaccharide composed of galactose and sulfate groups in a molar ratio of 1.0:0.89 together with uronic acids (6.8 wt %) and minor amounts of other neutral ...
Natural and semisynthetic diterpenoids with antiviral and immunomodulatory activities block the ERK signaling pathway
(Springer, 2015-10)
The pathogenesis of many viral infections lies on the damage caused by the immune response against the virus. Current antiviral drugs do not act on the inflammatory component of the disease. Thus, new compounds that inhibit ...
Ursolic acid: A novel antiviral compound inhibiting rotavirus infection in vitro
(Elsevier Science, 2019-11)
Rotavirus is one of the leading causes of severe acute gastroenteritis in children under 5 years of age, mainly affecting developing countries. Once the disease is acquired, no specific treatment is available; as such, the ...
ILF3 contributes to the establishment of the antiviral type i interferon program
(Oxford University Press, 2020-01)
Upon detection of viral infections, cells activate the expression of type I interferons (IFNs) and pro-inflammatory cytokines to control viral dissemination. As part of their antiviral response, cells also trigger the ...